Comments on: CBD Tolerance

By: Benefits of Dabbable CBD | CBD Consumption Method

Benefits of Dabbable CBD | CBD Consumption Method — Mon, 27 Jan 2020 17:04:18 +0000

[…] on feels will be less and it will take more for one to feel the effects. Although it is said that CBD does not build a tolerance, there is not enough research to determine if dabbing CBD creates a rapidly higher tolerance for […]

By: Infinite CBD

Infinite CBD — Tue, 10 Jul 2018 18:19:14 +0000

In reply to FW. Cycling your amount of CBD is said to be beneficial for this.

By: FW

FW — Thu, 22 Mar 2018 16:24:45 +0000

Not being a mouse, I can tell you that I develop a tolerance to CBD in a matter of a week or so, to the point that CDB basically becomes a placebo for me. If I stop using CBD for a couple weeks, I get a beneficial effect from it again, but daily use of CBD will pretty soon again cause a tolerance of CBD such that taking CBD becomes an expensive and useless endeavor for me. By the way, my dosages have been in the range of 1.5 mg to 6 mg per day (taken in the evening at or near bedtime).

By: vin

vin — Tue, 13 Mar 2018 06:53:29 +0000

In reply to Infinite CBD. ad I said, anxiolitic effect of CBD derive from agonism to 5ht1a receptor that is not a cannabinoid receptor. Of course cannabinoid receptor is not downregulated by cbd because it's a cannabinoid antagonist: cbd fights cannabinoid tolerance but probably reduce 5ht1a tolerance

By: Infinite CBD

Infinite CBD — Mon, 26 Feb 2018 20:06:15 +0000

In reply to CBD Oil Canada. Some research shows at micro doses of CBD the body will produce endocannabinoid receptors as well! There is still lots of research that needs to be done and on dosing as well!

By: CBD Oil Canada

CBD Oil Canada — Sun, 25 Feb 2018 20:24:17 +0000

I’ve tried multiple times to find if there’s a gained tolerance to CBD but have yet to find anything conclusive. The double blind mouse test is a good one, but inconclusive. That being said I have been using CBD for a minute and haven’t felt any negative effects.

By: Infinite CBD

Infinite CBD — Mon, 08 Jan 2018 14:14:39 +0000

In reply to Vin. Dr. Dustin Sulak D.O., says "Research has shown that small doses of cannabinoids from cannabis can signal the body to make more endocannabinoids and build more cannabinoid receptors.” This means when taken in small doses overtime, you will have produced more endocannabinoids and their receptors, actually increasing ones sensibility.

By: Vin

Vin — Sun, 24 Dec 2017 20:51:55 +0000

In reply to Vin.

https://www.ncbi.nlm.nih.gov/m/pubmed/22083592/

By: Vin

Vin — Sun, 24 Dec 2017 15:55:06 +0000

Every substance develop a certain amount of tolerance, including CBD. It doesn’t mean that you cannot get benefits from that substance if you still consumes it continously, but it depends on the purpose. As or CBD, if the purpose is (for example) anxiety control, long term use can nave a negative effect in an acute stress experience, because CB-n receptors are not the main receptor implied for the powerful CBD effects… You look at the wrong receptor! CBD works through 5ht1a receptor which have antipsychotic, ansiolitic and antidepressant effects, and you certainly develop tolerance to that receptor.

By: Mike reges

Mike reges — Wed, 29 Nov 2017 03:15:17 +0000

In reply to Jesse. November 28, 2017 Hey Jessie I have been searching the Web everywhere and I found this post. I believe we have similar issue I hope you can read this. Did you used to smoke weed then stop then use alot of cbd and now you can’t get high? Because that’s what I think happened to me.. I quit weed for a year used cbd for a year and now this is what happens. I get a good buzz in the morning but then by the late afternoon no matter how much I thc I consume I can’t get creative there is no euphoria and I just feel like wired normal it’s making worry..